Zoniporide hydrochloride

Research use only, not for human use.

Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets.

Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets.(In Vivo):In rats, Zoniporide hydrochloride (1 mg/kg; i.v.) shows the AUC0-∞ and t1/2 are 0.07 μg h/mL and 0.5 hours, respectively. In open chest anesthetized rabbits, Zoniporide hydrochloride (0.25, 1, 4 mg/kg; i.v.) dose-dependently reduces infarct size with an ED50 of 0.45 mg/kg/h. Zoniporide hydrochloride exhibits moderate plasma protein binding with t1/2 of 1.5h in monkeys.

CP-597396 hydrochloride

Membrane Transporter/Ion Channel

Sodium Channel

——

——

——

241800-97-5

356.8

C17H17ClN6O

>98% (HPLC)

——

Cl.O=C(NC(=N)N)C=1C=NN(C2=CC=CC3=NC=CC=C32)C1C4CC4

——

(-20℃)

With Ice Pack

≥ 2 years